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DH-1 for Diabetes Mellitus, Natural alternative for the treatment of diabetes mellitusDH-1 is an amazing edible herbal mixture for the treatment of diabetes mellitus, which mitigates the underlying pathologies and complications associated with this condition. The composition comprises a synergistic mixture of three herbs: Black Seed (Nigella sativa), Fenugreek (Trigonella foenum-graecum), and Chicory (Cichorium intybus). Fenugreek and Black Seed are well known for their anti-diabetic properties.
We believe that several synergistically acting compounds present in the herbal mixture are likely to be responsible for its pronounced anti-diabetic effects. It is used along with a diet and exercise program to control high blood sugar in patients with type-2 diabetes (non-insulin-dependent diabetes). We have formulated the herbal capsules with all the original qualities of the respective herbs intact.
Benefits of DH-1:
* Hypoglycemic effect (sugar lowering effect)
* Regulate the blood sugar level
* Improve pancreas function
* Cholesterol-lowering effect
* Improve spleen function
* Strengthen digestion
* Improve metabolism
* Reduce tiredness
* Counteract Thirst
Recommendation: Take 4 capsules twice a day, before breakfast and evening meal.
Attention: As most of the herbal medicine, it may take four to six weeks of treatment for effects to be noticed
Warning: If patient is currently taking oral drugs for diabetes or using insulin then they should continue in conjunction with the DH-1. The patient’s blood sugar level should be monitored closely by his or her health care provider. Dosing adjustments may be necessary once the DH-1 begins to take effect. Though eventually, the patient should be able to permanently discontinue taking oral drugs for diabetes or insulin upon completion of a course of treatment with the DH-1.
Evidence In a non-clinical study, 150 patients with diabetes mellitus were given 4 grams/day of DH-1 for 12 weeks. After this period, most of the patients were able to control their blood glucose level with DH-1 alone and they were able to discontinue the use of conventional drugs. Also many patients experienced an alleviation of problems associated with high blood sugar levels, including frequent urination, excessive thirst, nerve pain and skin infections.
It was also observed that some patients with type 1 diabetes were able to permanently discontinue taking insulin upon completion of a course of treatment with the DH-1.
The mechanism by which the herbal mixture operates is not exactly understood. However, it is theorized that DH-1 stimulates the pancreas to make its own insulin, interfere with carbohydrate absorption, and inhibit glucose transport. The ingredients in DH-1 have been the focus of numerous scientific studies validating their use.
Selected Scientific Studies
The blood sugar lowering effect of Black Seed and Fenugreek
Black Seed (Nigella sativa) also known as or Kalonji in Urdu and Hindi is one ingredient in the herbal mixture. The blood sugar lowering effect of this seed has been investigated in animal experiments, and the results have indicated that the seed extract is a useful therapeutic agent in the treatment of non-insulin dependent diabetes mellitus1-2.
In a recent comparative study the hypoglycemic effect (blood sugar lowering effect) of the volatile oils of Black Seed (Nigella sativa) relative to the oral hypoglycemic drug glipizide (also known as glibense, glucotrol) was examined on alloxan-induced diabetic rat. Oral administration of the oil showed significant elevation of the serum insulin levels relative to glipizide alone. The activity of glipizide, however showed a significant increase in hypoglycemic effect when administrated together with Black Seed (Nigella sativa) oil3.
Fenugreek (Trigonella foenum-graecum) is also known as Hilba in Arabic, Methi in Urdu and Sanskrit is another ingredient in the DH-1. There are several research centers studying Fenugreek hypoglycemic and lipid-lowering effects 4-9.
Test results suggest it can improve peripheral glucose utilization, which contributes improvement in glucose tolerance. Fenugreek appears to exert its hypoglycemic effect by acting at the insulin receptor as well as the gastrointestinal level. Randomized studies have confirmed Fenugreek helps stabilize blood sugar control in patients with insulin-dependent and non-insulin-dependent diabetes 10,11.
In another study, the effect of oral administration of sodium orthovanadate (SOV) and Fenugreek (Trigonella foenum graecum) seed powder (TSP), on the mitochondrial enzymes in tissues of alloxan-induced diabetic rats been investigated. This was the first report of the effective combined action of oral SOV and TSP in ameliorating the altered mitochondrial enzyme activities during experimental type-1 diabetes12.
Another study suggested that Fenugreek seeds have antioxidant properties and can be valuable candidates in the treatment of complications of diabeties13. It is believed that there are three primary constituents in Fenugreek that are key to its medicinal properties. A muscilaginous fiber (up to 50%), which is responsible for its soothing properties, gastrointestinal benefits, and to a certain extent, glucose modulating properties. Two compounds diosgenin (steroid) and trigonelline (alkaloid), which are responsible for its hormonal and glucose controlling actions14,15.
Reference:
1. Al-Awadi, F., et.al., The effect of plant mixture extract on liver gluconeogenesis in stretozotocin induced diabetic rats, Diabetes Research Clinical and Experimental, 18, 163-168 (1991).
2. Al-Awadi, F., et.al., On the mechanism of the hypoglycemic effect of a plant extract, Diabetologia , 28, 432-434 (1985).
3. Al-Zuhair, H. H., et.al., Hypoglycemic effect of volatile oils of Nigella sativa and Allium sativum and their interactions with glipizide on alloxan diabetic rats, Bull. Fac. Pharm., 34 (2), 101-104 (1996)
4. Abdel-Barry J. A., et.al., Hypoglycaemic effect of aqueous extract of the leaves of Trigonella foenum-graecum in healthy volunteers. East Mediterr Health J., 6(1), 83-88, (2000).
5. Neeraja, A., et.al., Hypoglycemic effect of processed fenugreek seeds in humans. J Food Sci Technol., 33(5), 427-430 (1996). 6. Sharma R. D., et.al., Use of fenugreek seed powder in the management of non-insulin dependent diabetes mellitus. Nutrit Res., 16(8),1331-1339 (1996).
7. Bordia A, et.al., Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostagland Leuk Essen Fat Acids, 56(5), 379-384 (1997).
8. Sharma, R., et.al., Hypolipidemic effect of Fungreek seeds: a Chronic study in non-insulin dependent diabetic patients, Phytotherapy Research, 10, 332-334 (1996)
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