Our most potent formulation, Biotic Detox Support delivers large amounts of specific probiotics to the intestinal tract to complement the Detoxamin Detoxification protocols such as eliminating broad-spectrum antibiotics, anti-fungal/anti-microbial medications, or heavy metal detoxification that can compromise friendly flora.

Biotic Detox Support probiotic supplement supplies large numbers of beneficial bacteria that support the body's natural detoxification process and help maintain a healthy balance of friendly intestinal flora during detoxification protocols such as antibiotic therapy, antifungal /anti-microbial medications, or heavy metal chelating agents. A total probiotic count of 50+ billion CFUs of a combination of Lactobacillus rhamnosus, Lactobacillus casei,and Bifidobacterium bifidumis provided in each capsule. Certified American Type Culture Collection (ATCC) probiotic strains of human origin are supplied in a base of inulin and encapsulated in two-piece Kosher-certified vegetarian capsules. Klaire's InTactic� acid-stable delivery technology, a proprietary hypoallergenic polysaccharide complex, is included to protect microorganism potency during transit through the acidic gastric environment. Biotic Detox Support is a hypoallergenic product free of common allergens, including dairy products, casein, gluten, corn, soy, egg, sugar, yeast, and maltodextrin. No artificial additives, colorings, flavoring, preservatives, or salicylates are used. A small amount of L-leucine, a naturally-occurring amino acid, is used as an encapsulation aid.

Role of Probiotics in Detoxification Processes
Probiotics may beneficially modulate intestinal detoxification functions that naturally contribute to a protective effect on the colon. Gut flora, especially following the ingestion of resistant starch, induces the chemo preventive enzyme glutathione transferase in the colon of the rat. In humans, the ingestion of probiotics leads to the excretion of urine with low concentrations of components that are genotoxic in human colon cells and high concentrations of components that induce oxidized DNA bases. When ingested with prebiotics, probiotics facilitate the production of high concentrations of short-chain fatty acids. Butyrate, an important short-chain fatty acid that serves as fuel for colon cells, may inhibit the genotoxic activity of nitrosamides and hydrogen peroxide in human colon cells. Direct binding of heterocyclic aromaticamines (HAs) to the cell walls of certain bacterial strains contained in fermented foods has been observed to take place under physiologically relevant conditions. These observations suggest that intestinal bacteria may be useful for dietary detoxification and protection strategies to facilitate removal of selected mutagens.

Role of Probiotics in Anti-Microbial Protocols
Administration of pharmaceutical drugs for treatment of bacterial, viral, yeast, or parasitic infections not only results in death of pathogenic organisms but also liberates a number of toxins, cellular debris, and by-products into the intestinal tract following death of the cell. The body's defenses are generally primed to respond to such an insult. However, use of these agents in individuals with compromised detoxification processes or gastrointestinal dysfunction may set the stage for adverse consequences that can manifest as a systemic (Herxheimer) reaction. The Herxheimer response (also described as a "die-off" reaction) can occur when live pathogens are killed and cellular toxins and by-products are released from lysed cells and transported into the circulation to be cleared from the body. Once absorbed into the bloodstream, these substances can cause adverse reactions that manifest as fatigue, skin hives, joint pain, or flu-like symptoms. Use of high potencies of probiotics can play a supportive role in clearing the released toxins and by-products from the intestinal tract before they have a chance to be absorbed, thereby lessening the likelihood of adverse responses.

PROBIOTIC STRAINS
Biotic Detox Support supplies high concentrations of three selected probiotic strains noted for protective activities as follows:
Lactobacilllus rhamnosus As a primary resident of the small intestine, Lactobacilllus rhamnosusadheres to and colonizes the mucosal membrane where it exerts important health-promoting functions. It enhances cellular immunity by increasing immunoglobulin IgA and stimulating phagocytosis. It also reduces intestinal inflammation and mucosal barrier permeability in infants with allergic dermatitis. This strain functions by competitive exclusion ofpathogenic organisms including E. coli, Listeria, Clostridia, Shigella and Salmonella, etc. L. rhamnosus can also assist the immune system in resisting pathogenic organisms such as bacteria and yeast that promoteintestinal inflammation and damage membranes.

Lactobacillus casei L.caseiis a common lactic acid bacteria found in the mouth and membrane of the small intestine where it shares many of the same immune-modulating effects exerted by other lactobacilli family members. It helps intestinal cells respond appropriately when the immune system is challenged by enhancing the number of IgA-producing cells in the mucosal membrane. T-lymphocytes, which have an important role in the mucosal immune response, are also increased by higher populations of L. casei.The cell wall of the L. casei strain contains teichoic acid which participates in adherence of L. caseito epithelial tissue where it inhibits attachment of pathogenic organisms. A protective effect against DNA damage in cells in the GI tract has been observed when high concentrations of L. caseiare administered prior to carcinogen exposure in rats. Bifidobacterium bifidum

B. bifidum(also recognized as B. lactis)is primarily found in the digestive system of adults and children, but is especially important to and prevalent in high numbers in breastfed infants. B. bifidumis a common resident in the mucus membranes lining the distal part of the small intestine, the large intestine, and the vaginal tract, where it attaches to the luminal walls, crowding out yeast (Candida albicans)and pathogens(Clostridium, Salmonella, etc.) by competing for nutrients. B. bifidumalso produces acetic and lactic acid, which lowers the pH (increases the acidity) of the intestine, thus inhibiting growth of undesirable bacteria. A role in detoxification has been demonstrated with use of this bifidobacterium strain. B. bifidum administered to 20 patients with liver disease produced a significant decrease in blood ammonia, free serum phenol, and free amino nitrogen.

INULIN OLIGOSACCHARIDE BASE
Inulin is a natural, non-digestible oligosaccharide derived from the chicory root vegetable. Recognized for its ability to function as a "pre-biotic", inulin is used a fuel source to stimulate or increase the growth of beneficial bacteria (Bifidobacteria)which have a role in reducing the growth of pathogens in the intestinal tract. This naturally-derived base ingredient is generally well-tolerated by the highly sensitive patient. It isused in place of corn- or wheat-derived maltodextrin, commonly use as a base ingredient in the majority of probiotic supplements.

INTACTICTM ACID-STABLE DELIVERY SYSTEM Probiotic viability of Biotic Detox Support is protected by InTactic� acid stable technology. InTactic� is highly purified polysaccharide material of marine origin that forms a gel-like matrix that surrounds and protects the probiotic bacteria from destruction by gastric acid. This allows the friendly flora to survive exposure to stomach acids and be delivered alive into the small intestines where they are released intact to exert their health promoting function.

INDICATIONS: Biotic Detox Support Support is recommended whenever support for intestinal detoxification mechanisms is indicated. It may be especially useful in conjunction with agents that may adversely affect the population of beneficial intestinal flora, including during and following use of broad-spectrum antibiotics, anti-microbial or anti-parasitic medications, anti-fungals/anti-candida drugs, or heavy metal chelating compounds. Biotic Detox Support may also be used whenever an intensive approach toreplacement with large quantities of probiotic Lactobacillus and Bifidobacteriumis desired.

SUGGESTED USE: One capsule daily or as directed by physician. Capsules may be pulled apart and contents taken separately if desired.