is a dipeptide composed of the amino acids beta-alanine and
L-histidine. It occurs naturally in muscle, brain and other tissues in
high concentrations. In vitro studies, l-carnosine reduced glycation, a
process in which DNA and protein are damaged by glucose
carnosine (also known as L-carnosine) has been known for about a
century, its antiaging properties have only been extensively studied
during the past few years. A recent literature review revealed over 780
published studies on carnosine, mainly by Russian and Japanese
researchers. However, more widespread interest in this natural nontoxic
product has only recently been increased, fuelled by dramatic
Australian and British discoveries about its antiaging actions (1). to
(B-alanyl-L-histidine) is a naturally-occurring di-peptide (a
combination of two amino acids), found in muscle, brain and other
innervated animal and human tissues. It is formed by a process
involving the enzyme carnosine-synthetase which bonds the amino acids
alinine and histidine. This process occurs mainly in muscles and brain.
It is kept in equilibrium by the carnisinases which are enzymes
specifically aimed at inactivating carnosine in the tissues or in the
are several other related dipeptides such as carcinine, anserrine,
homocarnosine and ophidine, all of which are naturally-occurring. These
are believed to be buffering agents, helping to maintain the
homeostatic equilibrium (2).
concentrations of carnosine are present in long-lived cells (such as in
neuronal tissues). The concentration of carnosine in muscles correlates
with maximum lifespan, a fact that makes it a promising bio-marker of
aging. It is high in actively contracting muscles and low in cases of
muscular disease such as Duchennes's muscular dystrophy. Its
concentration in mammalian muscles possibly decreases with age, a fact
which strengthens the case for supplementation.
Suggested Use: 1-3 tablets daily with meals.
1 tablet contains: L-Carnosine - 500 mg.